Effect of HITHOC After Pleurectomy Decortication for Treatment of Malignant Pleural Mesothelioma

Primary Outcome Measures

1. disease free survival or time to recurrence [ Time Frame: Through out the whole study with maximum of 2 years ]
   time from clearance of disease till onset of recurrence of same disease
2. overall survival [ Time Frame: till mortality of the case or 2 years maximum ]
   survival of the cases till mortality

Secondary Outcome Measures

1. comorbidities [ Time Frame: Through out the whole study duration with maximum of two years ]
   complications that may encounter either pre , intra or post intervention

Inclusion Criteria

• patients presented with localised MPM are the main target and histopathological diagnosis of MPM is made via video-assisted thoracoscopic surgery or open multiple pleural biopsies.

Exclusion Criteria

• patients with stage III or IV MPM in which cytoreductive surgery has no role.
• Patients underwent extrapleural pneumonectomy (EPP) as a cytoreductive surgery , because we are focusing on P/D only either conventional P/D or extended P/D