Primary Outcome Measures Establish the recommended phase 2 dose (RP2D) of TNhYP218 CAR T cells based on dose-limiting toxicity (DLT) of defined adverse events (AEs). Determine the preliminary objective response rate of TNhYP218 CAR T cells in a limited number of participants with mesothelioma treated at the recommended phase 2[…]
From the blog
Surgeries for Mesothelioma
Pleural mesothelioma is a very rare and aggressive cancer mainly caused by asbestos exposure. The survival time is very low, with people typically surviving around 9 to 20 months after treatment starts. The overall survival rate is around five percent, which means only five percent of people still live after[…]
Blood Biomarkers for Mesothelioma
A mesothelioma diagnosis is hard to receive and can be very overwhelming. Different research outcomes can help doctors and patients make better decisions though. One area of research is blood-based biomarkers. Two biomarkers that can help monitor mesothelioma include mesothelin-related protein (SMRP) and cancer antigen 125 (CA-125). They help monitor[…]
Chrysotile Asbestos Carcinogenesis
Mesothelioma, a tough to treat and severe cancer mainly caused by asbestos, continues to be a global health and safety issue. Chrysotile, the most abundant form of asbestos, is especially harmful due to how prevalent it is. Researchers looked at chrysotile and the heat-treated form forsterite to find the best[…]
Improving Mesothelioma Diagnosis
Malignant mesothelioma, an aggressive cancer mainly caused by asbestos, mainly affects the pleura, the lining of the lungs. It also affects the peritoneum, which is the lining of the abdomen. It is very tough to diagnose mesothelioma, which leads to underdiagnosis of the disease. A study in Brazil’s Sao Paulo[…]
Wildfires Continue to Affect Los Angeles Area
The Los Angeles County Sheriff’s Department issued warnings to Altadena deputies about toxins like asbestos being in the air. Deputies are recommended to wear N95 masks to help prevent toxin inhalation. The Fire Department’s hazmat team in Altadena said the air is hazardous, containing lead, asbestos, and other harmful particulates.[…]
Drug Factories to Treat Mesothelioma
Researchers from Rice University and Baylor College of Medicine developed a new treatment that can eliminate advanced stage mesothelioma tumors in mice within days. The breakthrough treatment used Rice’s cytokine drug factory implants with a checkpoint inhibitor drug. This combination is showing great potential in mesothelioma preclinical trials. The treatment[…]
Decision Making Tools for Mesothelioma
Mesothelioma, a cancer mainly caused by asbestos exposure, is very rare and aggressive. There are many challenges that doctors face when diagnosing, treating, and managing this cancer. Advances in medical technology and data analytics are helping doctors make crucial decisions for patients struggling with the hard to treat and deadly[…]
MARS 2 Trial for Mesothelioma
Malignant pleural mesothelioma is a deadly cancer mainly caused by asbestos exposure. It is a hard-to-treat cancer due to its aggressiveness. The cancer affects the pleura, which is the membrane that covers the lungs. A trial known as MARS 2 tried to find out if extended pleurectomy and decortication could[…]
Improving Mesothelioma Diagnosis
Malignant mesothelioma, an aggressive cancer mainly caused by asbestos exposure, mostly affects the pleura. The pleura is the membrane that surrounds the lungs. It can also harm tissues like the peritoneum, which is a membrane that surrounds the abdomen. Due to its rare nature and shared symptoms with other illnesses,[…]
