Multicentre Study Comparing Indwelling Pleural Catheter With Talc Pleurodesis for Malignant Pleural Effusion Management

Primary Outcome Measures:

• Number of hospital days for all causes following intervention [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

• Number of hospital days computed for pleural effusion related cause [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]
• Number of adverse events [ Time Frame: Up to 1 year ] [ Designated as safety issue: Yes ]
• Breathlessness score [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]
• Self-reported quality of life scores [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]
• Health costs computation [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]

Eligibility Criteria

Inclusion Criteria:

• Symptomatic malignant pleural effusion requiring intervention

Exclusion Criteria:

• <18 years of age
• pregnant or lactating patients
• expected survival <3 months
• chylothorax
• previous attempted pleurodesis
• pleural infection
• leukocytopaenia (<1.0 x 10^9/L)
• uncorrectable bleeding diathesis
• inability to give informed consent or comply with the protocol