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Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy

Published: August 23, 2010

Primary Outcome Measures:

Collect and store blood samples [ Time Frame: 1 year ] [ Designated as safety issue: No ]
To collect and store blood samples from patients with gastric cancer, GIST, esophageal cancer, pancreas cancer, hepatocellular cancer, biliary cancer, neuroendocrine, peritoneal mesothelioma, anal cancer and colorectal cancer.
create a database for the collected tissue [ Time Frame: 1 year ] [ Designated as safety issue: No ]
To create a database for the collected tissue and allow access to relevant clinical information for current and future protocols.

Secondary Outcome Measures:

To create tissue microarrays for each gastrointestinal cancer subtype [ Time Frame: 1 year ] [ Designated as safety issue: No ]
To create tissue microarrays for each gastrointestinal cancer subtype, and to facilitate future molecular studies. To grant access to this database (as it is being acquired) of the coupled patient tissue samples (normal and malignant) and relevant clinical information for the investigation of tyrosine kinases, such as Met and Ron, etc., and downstream targets implicated in the pathogenesis of GI cancers. Examples of molecular testing include evaluation of DNA mutation, alternative splice variants, protein expression and phosphorylation, and immunohistochemistry on samples.

Biospecimen Retention: Samples With DNA

blood, tissue, DNA


  • Gastric Cancer
  • Gastrointestinal Stromal Tumors (GIST)
  • Esophageal Cancer
  • Pancreas Cancer
  • Hepatocellular Cancer
  • Biliary Cancer
  • Neuroendocrine Cancer
  • Peritoneal Mesothelioma
  • Anal Cancer
  • Colorectal Cancer

Eligibility Criteria

Study Population
Any patient having a biopsy or having surgery
Inclusion Criteria:
any patient diagnosed with Gastric (stomach) Cancer, Esophageal (foodpipe) Cancer, Pancreas Cancer, Liver Cancer, Biliary (gallbladder) Cancer, Gastrointestinal Stromal Tumor, Peritoneal Mesothelioma (cancer in the lining of the abdomen), Neuroendocrine (of or relating to the cells that release a hormone into the blood in response to a neural stimulus) Tumor, Anal Cancer or Colorectal Cancer cancer that requires you to undergo a surgical or diagnostic procedure.
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