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11C-Methionine PET/CT Imaging in Patients Affected by Malignant Pleural Mesothelioma (MPM)

Published: July 27, 2016

Primary Outcome

  • Variation of SUVmax (Maximal Standardized Uptake Value) in patients undergoing talc pleurodesis [ Time Frame: Change from Baseline in SUVmax up to 1 week after talc pleurodesis. ] [ Designated as safety issue: No ]

Detailed Description

This is a single-center, open-label study, lasting 36 months including an estimated period of 24 months for the enrollment and max 12 months of follow-up. All patients affected by MPM and referred to our Institution eligible for therapeutic pleurodesis and subsequent platinum- and pemetrexed-based chemotherapy will be enrolled. In all cases patients will be investigated with 11C-Methionine PET/CT and 18F-FDG PET/CT before talc pleurodesis, one week after and at the end of three cycles of chemotherapy. A minimum number of 20 patients will be considered for the analysis.

Study Population

All patients affected by MPM and referred to our Institution for therapeutic pleurodesis and subsequent platinum- and pemetrexed-based chemotherapy will be enrolled. A minimum number of 20 patients will be considered for the analysis.

Eligibility

Inclusion List
patients with an histological diagnosis of MPM eligible for pleurodesis and scheduled to undergo platinum- and pemetrexed-based chemotherapy.
obtained informed consent
Exclusion Criteria
patients age <18 years
pregnancy or breast-feeding;
patients affected by other malignancies within the last 3 years;
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