This is a multi-centre non-randomised open-label phase 1 trial of pembrolizumab given in combination with SBRT to part of a pleural-based lesion in patients with unresectable MPM. This study will recruit up to 18 patients whose MPM has progressed beyond first-line of palliative chemotherapy, with a platinum-based doublet, and now requires further palliative systemic treatment, or have declined first-line palliative chemotherapy, however must have been considered suitable for a platinum doublet chemotherapy.
From the blog
CRISPR Could be used on Mesothelioma Patients Soon
Using CRISPR, scientists may be able to treat mesothelioma patients. They are testing the safety of CRISPR on cancer patients, and this could have large effects on future patients including those suffering from mesothelioma. CRISPR gene editing is a technique created by scientists that mimics the way bacteria cells defend[…]
A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma
This study will test whether giving nivolumab in combination with pemetrexed and either cisplatin or carboplatin before surgery is a safe and effective approach to treating resectable mesothelioma without delaying surgery.
A Study of Pembrolizumab in Combination With Cisplatin and Pemetrexed in Advanced Malignant Pleural Mesothelioma (MPM) (MK-3475-A17)
Primary Outcome Measures Number of Participants Who Experience a Dose-limiting Toxicity (DLT) Per Common Terminology Criteria for Adverse Events (AEs), Version 5.0 (CTCAE) [ Time Frame: Up to 3 weeks ] DLTs will be assessed during the first cycle (21 days) and are defined as Grade (Gr) 4 hematologic toxicities (any period), except neutropenia[…]
There is a Possible New Way to Diagnose Pleural Mesothelioma
Researchers have possibly found a less invasive way to diagnose pleural mesothelioma. By looking at the patient’s medical history and using CT scans, researchers at the Universite Laval in Quebec have found that imaging technology can be used potentially to benefit very sick patients. Doctors have never been able to[…]
Lung Cancer Awareness Month Starts Today
Today starts Lung Cancer Awareness Month. In November, we come together to recognize this deadly cancer and learn about different causes and treatments. Knowing the different statistics and causes could help save a lot of people’s lives. Lung cancer is the leading cause of death due to cancer in men[…]
