Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos

Primary Outcome Measures:

• Development of Model to Predict Workers at highest risk of lung cancer/mesothelioma [ Time Frame: 3 years ] [ Designated as safety issue: No ]

Eligibility Criteria

Study Population

Workers in British Columbia who have been exposed to asbestos.

Inclusion Criteria:

• Women or men age 50 to 79 years
• history of exposure to asbestos at work and one or more of the following:
  • lung cancer risk ≥2% over 3 years or
  • asbestosis or pleural plaques on a chest x-ray or
  • abnormal auto-antibodies level using the EarlyCDT test
• Capable of providing informed consent for screening procedures (low dose spiral CT, lung function, blood biomarkers).

Exclusion Criteria:

• Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, or any disorder, that in the opinion of the physician unlikely to benefit from screening due to shortened life-expectancy from co-existing illnesses
• Have been previously diagnosed with mesothelioma
• Have had other cancer within the past 5 years with the exception of the following cancers: non-melanomatous skin cancer,localized prostate cancer, carcinoma in situ (CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must have ended >6 months before registration into this study
• Pregnancy
• Unwilling to have a low dose CT scan of chest
• Unwilling to sign a consent