Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma

Primary Outcome Measures

1. Higher Sensitivity for detection using New High Resolution Contrast Enhanced MRI Imaging Sequences compared to standard MRI [ Time Frame: 60 Days ]New HR-MRI sequences will demonstrate greater sensitivity than standard MRI for detecting peritoneal metastases.
2. Higher sensitivity for detection of peritoneal metastatic disease using Ultrasound Elastography compared to standard MRI [ Time Frame: 60 Days ]Ultrasound Elastography will demonstrate greater sensitivity than standard MRI for detecting peritoneal metastases.

Secondary Outcome Measures

1. The performance of diffusion-weighted MRI in detecting peritoneal disease in patients with malignant peritoneal mesothelioma [ Time Frame: 60 days ]Use diffusion-weighted MRI in detecting the per-region sensitivity in patients with MPM
2. Test high-definition small-voxel MRI imaging sequences for detection of peritoneal disease in MPM [ Time Frame: 60 days ]To test HR-MRI sequences for detection of peritoneal disease in MPM focusing on the right hemidiaphragmatic and pelvic spaces
3. Perform Ultrasound Elastography in peritoneal mesothelioma to determine optimal strain ratios [ Time Frame: 60 days ]Ultrasound Elastography to determine optimal strain ratios to maximize sensitivity in PM patients
4. Perform Ultrasound Elastography in peritoneal mesothelioma to determine elasticity scores [ Time Frame: 60 days ]Ultrasound Elastography to determine elasticity scores to maximize sensitivity in PM patients

Inclusion Criteria

1. 18 years old or older
2. Biopsy-proven MPM
3. Surgery for PM planned at UCM within 60 days
4. Able to tolerate CT, MRI, US scans, and surgery
5. Able to provide written informed consent
6. For women of child bearing age, ability and willingness to use appropriate contraceptive methods before imaging and for a period of 365 days thereafter.

Exclusion Criteria

1. Pregnancy / Breastfeeding
2. Allergy or intolerance to iodinated or gadolinum contrast dyes
3. Contraindications to CT or MRI imaging including chronic kidney disease with GFR <60mL/min/1.73m2
4. Bioimplants unsuitable for MRI imaging (activated by mechanical, electronic, radiofrequency, or magnetic means), such as cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps
5. Permanent tattoos or eyeliner with magnetic dyes
6. Subjects with shrapnel or metal fragments lodged in the body
7. Anxiety, claustrophobia, or any medical condition that would preclude lying still in an MRI scanner for 1-1.5 hours
8. Cardiac, circulatory, or perspiration problems leading to impaired thermoregulation
9. Respiratory or cardiac impairment limiting the ability to lie flat
10. Inability to breath-hold for MRI acquisition
11. Vascular or aneurysm clips or any other surgical implant that is not MRI-compatible
12. Any other ferromagnetic bioimplant that would be damaged by MRI
13. Mental, cognitive, or mental health impairments that preclude the subject from providing informed consent or adhering to the treatment protocol
14. Subjects unable to adhere to the protocol or communicate effectively with researchers
15. Imprisoned subjects
16. Subjects with history of prior CRS/HIPEC or other peritonectomy surgery that might alter characteristics of the peritoneum