Mesothelioma Early Detection by VOCs (MED-VOC)

Primary Outcome Measures

1. VOC markers in breath samples. Predictive capability, sensitivity and specificity of biomarkers present in volatile organic compounds (VOC) for the early detection of pleural Mesothelioma in patients exposed to asbestos. [ Time Frame: By March 31, 2021 ]Predictive capability, sensitivity and specificity of biomarkers present in volatile organic compounds (VOC) for the early detection of pleural Mesothelioma in patients exposed to asbestos.

Secondary Outcome Measures

1. Predictive capability, sensitivity and specificity of Soluble Mesothelin Related Peptides (SMRP) in serum when combined with VOC biomarkers for pleural mesothelioma. [ Time Frame: By March 31, 2021 ]Determine the additive predictive capability, sensitivity and specificity of SMRP serum biomarkers with VOC biomarkers for the early detection of pleural mesothelioma

Inclusion Criteria

• Male or Female over 18 years of age
• Clinical diagnosis of pleural mesothelioma or presence of pleural plaques on X-Ray
• Documented exposure to asbestos
• Must be able to provide breath sample
• Must be able to provide relevant medical information

Exclusion Criteria

• Presence of malignancies other that mesothelioma within the past 6 months
• Treatment for any malignancies other than mesothelioma within the past 6 months
• Inability to provide past clinical information
• Inability to perform breath collection procedure
• Smoking or consuming alcohol within two hours of conducting breath collection procedure