Primary Outcome Measures:
- Correlation of optical coherence tomography images of the airway with airway histology [ Time Frame: This study will involve discarded tissue from 10 subjects with pathology specimens over one year. ] [ Designated as safety issue: No ]
Intervention Details:
- Procedure: bronchoscopic and lung imaging studies
- Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.
- Procedure: diagnostic bronchoscopy
- Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.
- Procedure: histopathologic examination
- All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.
- Procedure: optical coherence tomography
- Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.
Detailed Description
Objectives:
- Correlate optical coherence tomography images of the airway with airway histology.
- Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.
Outline: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.
Criteria
- Disease Characteristics:
-
- Undergoing pneumonectomy or lobectomy for malignant or benign lung processes
- Patient Characteristics:
-
- Not specified
- Prior Concurrent Therapy:
-
- See Disease Characteristics
