In a study presented today at the American Association for Cancer Research Annual Meeting 2024, researchers at Fox Chase Cancer Center showed that mice with a BAP1 germline mutation, after exposure to small levels of asbestos, had a greater chance of developing malignant mesothelioma. The study is being published in[…]
From the blog
Researchers Looked at Fibroblasts to Determine Their Role in Mesothelioma Growth
Malignant mesothelioma is a hard cancer to treat and is mainly caused by asbestos. It was widely used in construction, steel mills, and other industries. Mesothelioma is especially hard to treat because it grows and spreads quickly. There are unfortunately not many options for the treatment of mesothelioma. It takes[…]
A Phase 1a/1b Study of ACTM-838 in Patients With Advanced Solid Tumors
This is a first in human (FIH) 2-part study using ACTM-838 in patients with advanced solid tumors resistant to standard of care treatment. Part 1a will evaluate dose escalation and Part 1b will evaluate dose expansion.
Targeting uPARAP Could Improve Mesothelioma Treatment
Mesothelioma is a hard cancer to treat that has low survival rates. This makes it a problem for doctors and researchers. A new study is looking to change this by looking at the collagen receptor uPARAP. The current clinical trial is looking at uPARAP, a protein that is found in[…]
Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma (PENINSULA)
In this Phase-II study, the investigators will investigate the efficacy and safety of lenvatinib in combination with pembrolizumab and chemotherapy in patients with malignant pleural mesothelioma.
3D Printing and Optical Scanning Can Improve Mesothelioma Treatment
New treatments and technologies offer hope for mesothelioma patients. One technology, 3D printing and optical scanning, has the potential to help those suffering with mesothelioma. The technologies refine and enhance what is known as photodynamic therapy, a promising new approach for the management of mesothelioma. Photodynamic therapy is a unique[…]
Exercise to Boost Immunity in Advanced Cancer (BICEP)
The trial is a prospective feasibility trial conducted in Sheffield. Recruitment will include twenty patients receiving first line palliative immunotherapy for advanced, unresectable or metastatic mesothelioma and patients receiving first line systemic anti-cancer treatment for pancreatic cancer. Patients will attend the AWRC for a supervised exercise session once a week to include aerobic exercise along with an unsupervised weekly exercise session for 3 months. Blood samples will be collected at baseline and then monthly for 3 months, pre and post the supervised exercise session. Cytokine, myokine and immune cell concentration will be analysed using cytokine bead-based multiplex immune assays and RNA-seq to full profile changes in gene and protein expression
An Iowa School was Fined for Exposing Workers to Asbestos
An Iowa school district could be fined thousands of dollars for having employees work inside an asbestos-contaminated building. State records were recently released showing that the Iowa Occupational Safety and Health Administration fined the school district $70,000. The school district was also fined another $6,000 by the Iowa Department of[…]
NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended Phase 2 dose, define the pharmacokinetics, to explore the pharmacodynamics, and to obtain preliminary evidence of the clinical activity in adult patients with selected advanced solid tumors.
Imerys Talc America and Cyprus Mines Corporation are Creating a Trust for Asbestos Victims
Imerys Talc America and its former owner, Cyprus Mines Corporation, will create a collective $862 million trust. The reason for the trust is to settle personal injury claims that allege the company’s asbestos contaminated talc caused people’s cancer. This is after both groups filed reorganization plans and disclosure statements on[…]
