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Targeting uPARAP Could Improve Mesothelioma Treatment

Published: March 28, 2024

Mesothelioma is a hard cancer to treat that has low survival rates. This makes it a problem for doctors and researchers. A new study is looking to change this by looking at the collagen receptor uPARAP. The current clinical trial is looking at uPARAP, a protein that is found in higher levels in mesothelioma cells. Researchers noticed that uPARAP could be a potential target for treating mesothelioma, and this could lead to new treatments for the disease. Researchers looked at tissue samples and found that all types of mesothelioma cells had high levels of uPARAP. This could mean that different people could need different treatments based on uPARAP levels.

The study also looked at the efficacy of the drugs against mesothelioma cells in a lab. It was found that the drugs can kill mesothelioma cells well. This means there could be potential for the drugs to work well against mesothelioma and possibly other cancers. In a different study, the drugs that target uPARAP were tested in mice with mesothelioma. A drug targeting uPARAP was used. It showed good promise since it slowed tumor growth and reduced tumor size. This shows that drugs that target uPARAP could be beneficial for the treatment of mesothelioma.

A different study is looking at CAR T cell therapy to target uPARAP. The study is still in early stages, but this could be an effective way to treat mesothelioma. Doctors are constantly learning about mesothelioma and what they learn is put into practice. As they learn more about uPARAP and its effect on mesothelioma, doctors will be able to target the protein and exploit what they find on mesothelioma. Clinical trials are an important part of the cancer treatment process. Without clinical trials, we would not be where we are today with the treatment of cancer. Many mesothelioma sufferers’ live have been lengthened due to research.

Mesothelioma is a cancer of the mesothelium, which is a lining of certain areas of the body including the lungs, abdomen, heart, and testicles. When people are exposed to asbestos, fibers become lodged in the mesothelium, where inflammation and DNA changes occur. This then leads to regular mesothelium cells turning into mesothelioma cells. Research is the best option to lengthen the lives of people with mesothelioma and could even one day lead to a cure for the disease.

Pinar Çakılkaya, “The Collagen Receptor uPARAP as a Therapeutic Target for Mesothelioma” Copenhagen University Hospitals (2024). [Link]
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