From the blog

Photodynamic Therapy to Treat Mesothelioma

Published: February 20, 2026

Cancer treatment has made significant improvements in recent years, thanks to advancements in technology. One technology being used is 3D printing and scanning. Together they are enhancing the accuracy and effectiveness of cancer treatments. This includes photodynamic therapy for malignant pleural mesothelioma and other cancers.

Photodynamic therapy (PDT) is a promising treatment for mesothelioma and other cancers. It utilizes a photosensitizing agent that is activated by light to kill cancer cells. Delivering the right dose of light to the tumor can be challenging though, especially in cases when the anatomy has been altered by surgery.

3D printing has also emerged as a promising treatment tool against cancer. We can now create precise, patient-specific 3D models of the affected area. Doctors can then plan the optimal treatment strategy better. In the case of mesothelioma, 3D printing can help create models of the pleural cavity, allowing for more accurate PDT dosing. The process starts by obtaining detailed imaging, such as CT scans, of the affected area. These scans are then used to create a 3D model, which is then printed using specialized materials. These 3D models accurately replicate the patient’s anatomy. This includes any post-surgical changes. It provides doctors with a clear view of the affected area.

By using 3D models, doctors can better visualize the tumor and surrounding tissues. This helps them to plan the photodynamic therapy more accurately. This precision ensures that the right amount of light is delivered to the tumor. It also maximizes treatment effectiveness while minimizing damage to surrounding tissue. Validation studies have confirmed the usefulness of this technology in improving cancer treatment outcomes. The use of 3D printing and scanning can also be applied to surgery planning and radiation therapy.

3D printing and scanning technology are revolutionizing cancer treatment by providing doctors with a more accurate and personalized approach. For mesothelioma, this technology offers new hope for improved treatment outcomes. As technology continues to advance, we can expect further innovations that will continue to enhance cancer treatment and improve patient outcomes.

Research and developing new technologies for the treatment of hard-to-treat cancers is essential. Without developing new technologies and advancing treatments, we would not be where we are today in the treatment of mesothelioma and other hard to treat cancers. With continuing research, maybe one day a cure for mesothelioma could be found. Until then, research needs to continue, and more people need to sign up for clinical trials so one day a cure can be found for mesothelioma and other hard to treat cancers.

Source:
Dennis Sourvanos et al., “Enhanced photodynamic therapy delivery for malignant pleural mesothelioma using 3D-printed models and optical scanning technology” Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodyanamic Therapy XXXII (March 12, 2024). [Link]
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